Nourishing the Brain with Organ Meats: Nutrients that Enhance Mental Health

Organ meats like liver, heart, kidneys, and even brain have been cherished in traditional diets across cultures for thousands of years. These foods weren’t just eaten because they were there; they were valued for their incredible nutrition and how they helped keep people healthy and strong. People understood that these parts of the animal held something special—nutrients that kept the body energized, resilient, and capable of facing the demands of daily life.1

Today, as more of us turn back to ancestral ways of eating, we’re rediscovering why these nutrient-packed foods have held such high regard. Organ meats offer an unmatched range of vitamins and minerals that modern diets often miss, making them a true “superfood” for anyone looking to boost their health naturally.

Today, as modern science uncovers more about the intricate connections between nutrition and brain health, we can see why these organs are highly regarded. As neurodegenerative diseases and mood disorders become more common, it’s more important than ever to understand how nutrient deficiencies impact brain health. Packed with essential vitamins, minerals, and compounds in highly bioavailable forms, organ meats deliver unparalleled support for cognitive health, emotional stability, and mental clarity.2

Let’s examine how the nutrients in organ meat contribute to brain health, their specific roles, and what happens when our diets fall short.

Iron 

Organ meats contain bioavailable heme iron, offering one of the richest natural sources of this vital nutrient. Iron is central in oxygenating the brain and is essential for energy production within brain cells. It facilitates the production of neurotransmitters such as dopamine and serotonin, which regulate mood, motivation, and emotional stability. When iron levels are sufficient, the brain remains well-oxygenated and energized, supporting sharp thinking, focus, and a positive mood.3

Iron deficiency—often marked by symptoms like fatigue, brain fog, and low energy—can lead to impaired cognitive function and is associated with depressive symptoms. When iron levels are low, people can experience a drop in motivation, memory issues, and even a higher risk of neurodegenerative diseases. The brain simply isn’t getting the oxygen and energy it needs to work at its best.4

Selenium

Organ meats are rich in selenium, a powerful antioxidant that shields the brain from oxidative stress—a key factor in aging and neurodegenerative diseases. Selenium is crucial for producing glutathione peroxidase, an enzyme that protects neurons from free radical damage. Having enough selenium helps lower inflammation and boosts the brain’s resilience overall.5,6

When selenium is lacking, the brain becomes more vulnerable to oxidative damage, which can accelerate cognitive decline, increase the risk of Alzheimer’s, and disrupt mood stability. Low selenium levels have also been associated with higher levels of anxiety, irritability, and mood swings, as oxidative stress begins to interfere with the brain’s normal functions.7

Vitamin A

Organ meats are an excellent source of vitamin A, particularly in its retinol form, which is crucial for preserving the structure of neurons and supporting neurotransmitter function. Retinol aids in creating new brain cells and plays a role in gene expression, helping to regulate the growth and repair of brain cells. Vitamin A also contributes to dopamine production, which is essential for maintaining motivation, focus, and mental clarity.8

When vitamin A levels are low, cognitive issues can arise because neurons aren’t as well-protected, and neurotransmitter balance becomes disrupted. A deficiency in vitamin A can lead to memory difficulties, slower learning, and an increased risk of mood disorders, as dopamine levels may not be sufficient to support steady motivation and emotional stability.9

Zinc

Organ meats are rich in zinc, a mineral essential for neurotransmitter function, neuronal signaling, and neuroplasticity—the brain’s ability to adapt and form new connections. Zinc plays a crucial role in regulating GABA and serotonin, which help reduce anxiety and promote relaxation. Its neuroprotective properties also shield brain cells from free radical damage, safeguarding them against oxidative stress.10

A deficiency in zinc can lead to a variety of cognitive and emotional difficulties, ranging from anxiety and irritability to more severe mood issues, including depression. When zinc levels are low, it can also become harder to remember things and learn new information, as the brain’s ability to form and strengthen connections becomes compromised.11

Potassium

Organ meats are a valuable source of potassium, which is essential for keeping the brain’s electrical signals running smoothly and allowing nerve cells to communicate effectively. Potassium also helps regulate fluid balance and supports the stability of neurons, which is critical for maintaining mental focus and clarity. With adequate potassium, people are less likely to experience mental fatigue, irritability, and confusion.12

When potassium levels drop, neurons have a harder time staying stable, leading to issues like brain fog, difficulty concentrating, and mood swings. If potassium deficiency persists, the brain’s communication network can start to break down, contributing to mental fatigue and potentially even cognitive decline over time.13

Magnesium

Magnesium, found abundantly in organ meats, plays a vital role in supporting brain health by aiding in neurotransmitter regulation, stress response, and neuroprotection. Known as a natural relaxant for the nervous system, magnesium helps lower cortisol levels and builds resilience against stress. It also plays a crucial part in producing serotonin, the “feel-good” neurotransmitter, which is essential for mood regulation.

When magnesium levels are low, the nervous system lacks the support it needs to stay balanced, which can lead to anxiety, depression, and heightened stress. In the brain, a deficiency in magnesium can cause neuroinflammation, a factor linked to cognitive decline and various mental health disorders, as the calming, protective effects of magnesium are no longer there to shield the brain from stress.14,15

Phosphorus

Phosphorus, found in organ meats, is a key building block of phospholipids, which are vital for maintaining the integrity of cell membranes in neurons. These phospholipids support effective communication between brain cells, making them essential for memory retention and mental alertness. Phosphorus is also crucial for producing ATP, the primary energy source that brain cells depend on to function properly.16

When phosphorus levels are low, the brain’s ability to generate energy is compromised, leading to reduced alertness, memory difficulties, and slower cognitive processing. Over time, a lack of phosphorus can weaken the structural stability of neurons, potentially contributing to progressive cognitive decline and ongoing memory challenges.17

Manganese

Manganese, abundant in organ meats, is an essential cofactor for enzymes that help produce neurotransmitters like dopamine, which plays a big role in mood and motivation. It also supports the body’s antioxidant defenses, protecting brain cells from oxidative stress and helping maintain mental clarity. Adequate manganese levels are key for keeping mood steady, building mental stamina, and supporting clear thinking.18

When manganese levels are low, the brain may struggle with neurotransmitter production and antioxidant protection, leading to mood swings, mental fatigue, and reduced cognitive function. Chronic manganese deficiency can increase vulnerability to depression and anxiety, as the brain becomes less resilient to stress and inflammation.19

Chromium

Chromium, found in organ meats, plays a key role in regulating blood sugar levels, which has a direct impact on brain health and energy. By helping to maintain stable blood sugar, chromium ensures the brain receives a steady supply of glucose, preventing the energy crashes that can lead to brain fog, irritability, and mood swings.20

When chromium levels are low, blood sugar regulation suffers, often resulting in symptoms like irritability, lack of focus, and mental fatigue. Over time, chronically unstable blood sugar can lead to neuroinflammation and cognitive decline, as the brain is subjected to constant energy fluctuations and the damaging effects of poor glucose control.21

Thiamin (Vitamin B1)

Thiamin is essential for glucose metabolism, a critical energy source for the brain. This vitamin plays a significant role in neurotransmitter synthesis and helps prevent the development of neurodegenerative conditions by preventing amyloid plaque buildup associated with Alzheimer’s.22, 23 

Thiamin deficiency can lead to cognitive impairments such as memory loss, reduced focus, and emotional instability as the brain’s energy production falters. In severe cases, prolonged thiamin deficiency can cause serious conditions like Wernicke-Korsakoff syndrome, a disorder characterized by severe memory issues, confusion, and personality changes due to glucose metabolism failure in the brain.22, 23

Choline

Choline is a precursor to acetylcholine, a neurotransmitter responsible for learning, memory, and muscle control. It also supports dopamine function, which affects motivation and reward pathways. Sufficient choline intake aids in maintaining acetylcholine levels, supporting efficient learning, sharp memory, and emotional resilience. 

Low choline levels can lead to memory problems, lack of motivation, and even cognitive decline. Research shows that CDP-choline supplements may boost dopamine receptors, which could help improve memory and protect against mental decline. Without enough choline, the brain has a harder time producing neurotransmitters, affecting both thinking and emotional balance.24

The Bioavailability Advantage of Organ Meats

When it comes to nutrient bioavailability—how efficiently nutrients are absorbed and used by the body—organ meats stand out as a highly effective source. Nutrients in animal-based foods, especially organ meats, are often in forms that the body can absorb more readily compared to plant-based sources. 

Why Are Plant Nutrients Less Bioavailable? Plant-based foods often contain compounds like phytates, oxalates, and tannins, which can bind to essential minerals such as iron, calcium, zinc, and magnesium, forming insoluble complexes. These complexes are difficult for the body to break down and absorb, resulting in reduced nutrient availability. Phytates, found in foods like legumes, nuts, and seeds, bind particularly to iron and zinc, decreasing their absorption. Oxalates, abundant in leafy greens like spinach, can form complexes with calcium and magnesium, preventing these minerals from being readily absorbed.25,26

In contrast, the nutrients in organ meats, such as heme iron, B vitamins, and essential fats, are in forms that are highly bioavailable. Heme iron, for example, found only in animal sources, is absorbed more efficiently than the non-heme iron found in plants, as it does not bind to phytates and is less affected by other dietary inhibitors.

Benefits of Bioavailable Nutrients in Organ Meats

With fewer anti-nutritional barriers, organ meats provide a rich and accessible source of brain-supporting nutrients. The bioavailability of these nutrients allows the body to utilize them effectively, which can help maintain cognitive function, support mood regulation, and promote mental clarity. Regular consumption of organ meats can provide a stable supply of essential nutrients to help guard against cognitive decline, stabilize mood, and enhance overall brain resilience.

Conclusion

Organ meats are a powerful tool for supporting optimal brain health and resilience. Organ meats provide key nutrients that are crucial for cognitive function, mood balance, and memory. In today’s diets, which often miss out on these nutrient-dense foods, adding organ meats is a simple, effective way to nourish the brain, help prevent cognitive decline, and support clear thinking and emotional health. For those looking to enhance brain health and protect against cognitive challenges, organ meats offer a unique, nutrient-dense solution that aligns with the body’s natural needs.

Citations: 

1. Beal, Ty, et al. "Friend or Foe? The Role of Animal-Source Foods in Healthy and Environmentally Sustainable Diets." The Journal of Nutrition, vol. 153, no. 5, 2023, pp. 1–12.

2. Wong, Nai Hui, et al. "Nutrient Density and Bioavailability of Organ Meats: A Review." Animal Frontiers, vol. 13, no. 2, 2023, pp. 11–18.

3. Beard, John L., et al. "Iron Deficiency Alters Brain Development and Functioning." The Journal of Nutrition, vol. 133, no. 5, 2003, pp. 1468S–1472S.

4. Youdim, M. B. H., et al. "Putative Biological Mechanisms of the Effect of Iron Deficiency on Brain Biochemistry and Behavior." The American Journal of Clinical Nutrition, vol. 50, no. 3, 1989, pp. 607–617.

5. Cardoso, Bruna R., et al. "Selenium Status, Cognitive Performance, and Mood in the Elderly: A Review." Current Psychiatry Reports, vol. 19, no. 2, 2017, pp. 1–9.

6. Rayman, Margaret P., et al. "Selenium and Its Role in the Maintenance of Cognitive Function in Aging: A Review." Nutrients, vol. 6, no. 9, 2014, pp. 3521–3544.

7. Gao, Shumin, et al. "Selenium Level and Cognitive Function in Rural Elderly Chinese." American Journal of Epidemiology, vol. 165, no. 8, 2007, pp. 955–965.

8. Husson, M., et al. "Expression of Neurogranin and Neuromodulin Is Affected in the Striatum of Vitamin A–Deprived Rats." Brain Research Molecular Brain Research, vol. 123, no. 1-2, 2004, pp. 7–17.

9. Cocco, S., et al. "Vitamin A Deficiency Produces Spatial Learning and Memory Impairment in Rats." Neuroscience, vol. 115, no. 2, 2002, pp. 475–482.

10. Bitanihirwe, Byron K. Y., and Michael G. Cunningham. "Zinc: The Brain's Dark Horse." Synapse, vol. 63, no. 11, 2009, pp. 1029–1049.

11. Mlyniec, Karolina, et al. "Zinc Deficiency Induces Behavioral Alterations in the Tail Suspension Test in Mice. Effect of Antidepressants." Pharmacological Reports, vol. 64, no. 2, 2012, pp. 249–255.

12. Fang, Xiang, et al. "Potassium Intake and the Risk of Stroke, Cardiovascular Disease, and All-Cause Mortality in the General Population: A Meta-Analysis of Cohort Studies." Nutrients, vol. 12, no. 4, 2020, article 1154.

13. Zhang, Yongjian, et al. "Association Between Dietary Potassium Intake and Cognitive Function Among US Adults Aged 60 and Over." Nutrients, vol. 12, no. 10, 2020, article 3157.

14. Geiger, H., and Wanner, C. "Magnesium in Disease." Clinical Kidney Journal, vol. 5, suppl. 1, 2012, pp. i25–i38.

15. Barbagallo, M., and Dominguez, L. J. "Magnesium and Aging." Current Pharmaceutical Design, vol. 16, no. 7, 2010, pp. 832–839.

16. Izawa, K. P., et al. "Relationship Between Serum Inorganic Phosphorus Levels and Cognitive Decline Over 2 Years in Older Adults with Pre-Dialysis Chronic Kidney Disease." Clinical and Experimental Nephrology, vol. 24, 2020, pp. 286–287.
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17. Kemi, V. E., et al. "Low Phosphorus Diets and Brain Function: A Review." Molecular Biology Reports, vol. 47, 2020, pp. 8171–8178.

18. Chen, P., et al. "Manganese Homeostasis in the Nervous System." Journal of Neurochemistry, vol. 134, no. 4, 2015, pp. 601–610.

19. Erikson, K. M., et al. "Manganese Neurotoxicity: A Focus on the Neonate." Pharmacology & Therapeutics, vol. 113, no. 2, 2007, pp. 369–377.

20. Anderson, Richard A., et al. "Chromium Supplementation Improves Insulin Sensitivity in People with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial." Diabetes Care, vol. 44, no. 5, 2021, pp. 1072–1079.

21. Hua, Y., et al. "Chromium Supplementation Improves Cognitive Performance and Alters Brain Glucose Utilization in Healthy Elderly." Nutrients, vol. 13, no. 3, 2021, article 1012.

22. Gibson, Gary E., et al. "Pharmacological Thiamine Levels as a Therapeutic Approach in Alzheimer's Disease." Frontiers in Medicine, vol. 9, 2022, article 1033272.

23. Liu, Chengzhang, et al. "J-Shaped Association Between Dietary Thiamine Intake and the Risk of Cognitive Decline in Cognitively Healthy, Older Chinese Individuals." General Psychiatry, vol. 37, no. 1, 2024, article e101311.

24. Peng, Jieru, et al. "Dietary Choline Intake and Health Outcomes in U.S. Adults: Exploring the Impact on Cardiovascular Disease, Cancer Prevalence, and All-Cause Mortality." Journal of Health, Population and Nutrition, vol. 43, article 59, 2024.

25. Moghaddam, Nima, et al. "Bioavailability of Zinc and Iron in Plant-Based Diets and the Role of Anti-Nutritional Factors: A Review." Critical Reviews in Food Science and Nutrition, vol. 62, no. 17, 2022, pp. 4726–4740.

26. Greger, Michelle, et al. "Anti-Nutrients in Plant-Based Diets: Implications for Micronutrient Bioavailability and Health." Journal of Nutritional Biochemistry, vol. 110, 2023, article 109380.